ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

207

Symbol:

AKT1

Full Name:

v-akt murine thymoma viral oncogene homolog 1

Alias:

AKT|MGC99656|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q32.32|14q32.32

Physical Location:

104306730-104333124 on NC_000014.7, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 11651 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

AKT1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001014431.1	NP_001014431.1	NC_000014.7 range: 104306730..104333124, complement
NM_001014432.1	NP_001014432.1	NC_000014.7 range: 104306730..104333124, complement
NM_005163.2	NP_005154.2	NC_000014.7 range: 104306730..104333124, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (9381178\|9812896\|10485710\|10698680\|11715018\|12167717\|12244303\|12524439\|15183529\|15718470)
GO:0005886	plasma membrane	Cellular Component	IDA (14749367)
GO:0005886	plasma membrane	Cellular Component	EXP (10698680\|15808505)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005654	nucleoplasm	Cellular Component	EXP (9829964\|10490848\|11274386)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005524	ATP binding	Molecular Function	IC (11994271)
GO:0042802	identical protein binding	Molecular Function	IPI (7891724)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	EXP (9829964\|10490848\|11274386)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (11994271\|16139227)
GO:0005351	sugar:hydrogen symporter activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008286	insulin receptor signaling pathway	Biological Process	IMP (8978681)
GO:0008633	activation of pro-apoptotic gene products	Biological Process	EXP (15231831)
GO:0008643	carbohydrate transport	Biological Process	IEA
GO:0009408	response to heat	Biological Process	TAS (10958679)
GO:0018105	peptidyl-serine phosphorylation	Biological Process	IDA (16139227)
GO:0046777	protein amino acid autophosphorylation	Biological Process	TAS (16280327)
GO:0000060	protein import into nucleus, translocation	Biological Process	IMP (16280327)
GO:0007242	intracellular signaling cascade	Biological Process	IDA (14749367)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (10570282)
GO:0006924	activated T cell apoptosis	Biological Process	IMP (14749367)
GO:0005975	carbohydrate metabolic process	Biological Process	IEA
GO:0005978	glycogen biosynthetic process	Biological Process	IEA
GO:0006006	glucose metabolic process	Biological Process	IEA
GO:0006417	regulation of translation	Biological Process	IEA
GO:0006464	protein modification process	Biological Process	TAS (10570282)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006809	nitric oxide biosynthetic process	Biological Process	TAS (10376602)
GO:0006916	anti-apoptosis	Biological Process	TAS (10748004)
GO:0048009	insulin-like growth factor receptor signaling pathway	Biological Process	IMP (8978681)