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Gene Information
Gene ID:116554
Symbol:Mapk8
Full Name:mitogen-activated protein kinase 8
Alias:JNK
Organism:Rattus norvegicus (Rat)
Chromosome:16
Genetic Location:16p16
Physical Location:8922496-9004964 on NC_005115.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5599    Symbol (Name): MAPK8 (mitogen-activated protein kinase 8)
Ortholog Status:The human GeneID 5599 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:116554
Fold Change:0.631
P Value:0.038
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Name:15846778
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_341399.3XP_341400.3NC_005115.2 range: 8922496..9004964, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (10773432)
GO:0031982vesicleCellular ComponentIDA (16618812)
GO:0005737cytoplasmCellular ComponentISS
GO:0005634nucleusCellular ComponentISS
GO:0005634nucleusCellular ComponentIDA (16699462)
GO:0016740transferase activityMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIPI (16618812)
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionISS
GO:0004674protein serine/threonine kinase activityMolecular FunctionISS
GO:0004705JUN kinase activityMolecular FunctionISS
GO:0004705JUN kinase activityMolecular FunctionTAS (12011047)
GO:0004707MAP kinase activityMolecular FunctionIEA
GO:0043066negative regulation of apoptosisBiological ProcessISS
GO:0018107peptidyl-threonine phosphorylationBiological ProcessISS
GO:0030335positive regulation of cell migrationBiological ProcessIDA (12853963)
GO:0031116positive regulation of microtubule polymerizationBiological ProcessIMP (16618812)
GO:0031175neurite developmentBiological ProcessIMP (16618812)
GO:0043065positive regulation of apoptosisBiological ProcessIEP (16699462)
GO:0043066negative regulation of apoptosisBiological ProcessIDA (15309413)
GO:0042542response to hydrogen peroxideBiological ProcessIDA (14707549)
GO:0009411response to UVBiological ProcessISS
GO:0001503ossificationBiological ProcessISS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIDA (12011047)
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0006468protein amino acid phosphorylationBiological ProcessISS
GO:0006954inflammatory responseBiological ProcessIDA (11435459)
GO:0006970response to osmotic stressBiological ProcessIDA (10781376)
GO:0007165signal transductionBiological ProcessIDA (12011047)
GO:0007254JNK cascadeBiological ProcessISS
GO:0007258JUN phosphorylationBiological ProcessISS
GO:0009408response to heatBiological ProcessIDA (10772775)
GO:0048545response to steroid hormone stimulusBiological ProcessIEP (14512437)
Other Database Cross Links
NCBI Entrez Gene:116554
RGD:621506
Ensembl:ENSRNOG00000020155
dbSNP:Mapk8