ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Lrpap1

Full Name:

low density lipoprotein receptor-related protein associated protein 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

14q21

Physical Location:

81292620-81306703 on NC_005113.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4043 Symbol (Name): LRPAP1 (low density lipoprotein receptor-related protein associated protein 1)

Ortholog Status:

The human GeneID 4043 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.10293
Original ID2:		Lrpap1
Fold Change:		1.13
P Value:		0.00922
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_341239.2	XP_341240.2	NC_005113.2 range: 81292620..81306703

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0009986	cell surface	Cellular Component	IEA
GO:0031982	vesicle	Cellular Component	IDA (8223699)
GO:0048237	rough endoplasmic reticulum lumen	Cellular Component	IDA (8223699)
GO:0005515	protein binding	Molecular Function	IDA (16517593)
GO:0050750	low-density lipoprotein receptor binding	Molecular Function	IEA
GO:0008201	heparin binding	Molecular Function	IEA
GO:0050750	low-density lipoprotein receptor binding	Molecular Function	ISS