| Gene Information |
| Gene ID: | | 116646 |
| Symbol: | | Tpt1 |
| Full Name: | | tumor protein, translationally-controlled 1 |
| Alias: | | MGC105360 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 15 |
| Genetic Location: | | 15q11 |
| Physical Location: | | 56752463-56755287 on NC_005114.2 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 7178 Symbol (Name): TPT1 (tumor protein, translationally-controlled 1) |
| Ortholog Status: | | The human GeneID 7178 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Rn.36610 | | Original ID2: | | Tpt1 | | Fold Change: | | 1.31 | | P Value: | | 0.00065 | | Note: | | Lower levels in the hippocampus of iP than iNP rats |
| | Dataset Information | | Name: | | 15660665 | | Method: | | Microarray | | Tissue: | | Hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed | | Summary: | | The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01). |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0045298 | tubulin complex | Cellular Component | ISS | |
| GO:0005771 | multivesicular body | Cellular Component | ISS | |
| GO:0005737 | cytoplasm | Cellular Component | ISS | |
| GO:0005737 | cytoplasm | Cellular Component | IEA | |
| GO:0005615 | extracellular space | Cellular Component | ISS | |
| GO:0005515 | protein binding | Molecular Function | ISS | |
| GO:0005509 | calcium ion binding | Molecular Function | ISS | |
| GO:0005509 | calcium ion binding | Molecular Function | IEA | |
| GO:0006916 | anti-apoptosis | Biological Process | ISS | |
| GO:0007283 | spermatogenesis | Biological Process | IEP (11503212) | |
| GO:0008283 | cell proliferation | Biological Process | TAS (11503212) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 116646 |
| RGD: | | 621623 |
| Ensembl: | | ENSRNOG00000001049 |
| dbSNP: | | Tpt1 |
