ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

E2f5

Full Name:

E2F transcription factor 5

Alias:

E2f-5

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q23

Physical Location:

88346107-88361880 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1875 Symbol (Name): E2F5 (E2F transcription factor 5, p130-binding)

Ortholog Status:

The human GeneID 1875 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		E2f5
Fold Change:		1.19
P Value:		0.004
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_574892.2	XP_574892.1	NC_005101.2 range: 88346107..88361880, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0016528	sarcoplasm	Cellular Component	IDA (10725332)
GO:0005667	transcription factor complex	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (10725332)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (12063292)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI (12063292)
GO:0003700	transcription factor activity	Molecular Function	ISS
GO:0003700	transcription factor activity	Molecular Function	TAS (8589754)
GO:0009887	organ morphogenesis	Biological Process	ISS
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	TAS (8589754)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	ISS
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0051726	regulation of cell cycle	Biological Process	TAS (8589754)