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Gene Information
Gene ID:116663
Symbol:Dusp6
Full Name:dual specificity phosphatase 6
Alias:MGC93276
Organism:Rattus norvegicus (Rat)
Chromosome:7
Genetic Location:7q13
Physical Location:36893263-36897493 on NC_005106.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1848    Symbol (Name): DUSP6 (dual specificity phosphatase 6)
Ortholog Status:The human GeneID 1848 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Dusp6
Fold Change:1.13
P Value:0.006
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053883.2NP_446335.1NC_005106.2 range: 36893263..36897493
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIDA (8631996)
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0004725protein tyrosine phosphatase activityMolecular FunctionISS
GO:0004725protein tyrosine phosphatase activityMolecular FunctionIEA
GO:0004722protein serine/threonine phosphatase activityMolecular FunctionISS
GO:0004721phosphoprotein phosphatase activityMolecular FunctionISS
GO:0008138protein tyrosine/serine/threonine phosphatase activityMolecular FunctionIDA (8631996)
GO:0006470protein amino acid dephosphorylationBiological ProcessISS
GO:0006470protein amino acid dephosphorylationBiological ProcessIEA
GO:0000188inactivation of MAPK activityBiological ProcessISS
GO:0030154cell differentiationBiological ProcessIEP (8631996)
Other Database Cross Links
NCBI Entrez Gene:116663
RGD:70978
Ensembl:ENSRNOG00000023896
dbSNP:Dusp6