ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dusp6

Full Name:

dual specificity phosphatase 6

Alias:

MGC93276

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q13

Physical Location:

36893263-36897493 on NC_005106.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1848 Symbol (Name): DUSP6 (dual specificity phosphatase 6)

Ortholog Status:

The human GeneID 1848 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Dusp6
Fold Change:		1.13
P Value:		0.006
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053883.2	NP_446335.1	NC_005106.2 range: 36893263..36897493

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IDA (8631996)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	ISS
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IEA
GO:0004722	protein serine/threonine phosphatase activity	Molecular Function	ISS
GO:0004721	phosphoprotein phosphatase activity	Molecular Function	ISS
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Molecular Function	IDA (8631996)
GO:0006470	protein amino acid dephosphorylation	Biological Process	ISS
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA
GO:0000188	inactivation of MAPK activity	Biological Process	ISS
GO:0030154	cell differentiation	Biological Process	IEP (8631996)