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Gene Information
Gene ID:11668
Full Name:aldehyde dehydrogenase family 1, subfamily A1
Organism:Mus musculus (Mouse)
Genetic Location:19 B|19 12.0 cM
Physical Location:20676471-20717951 on NC_000085.5
Gene Type:protein-coding
Human Ortholog:GeneID: 216    Symbol (Name): ALDH1A1 (aldehyde dehydrogenase 1 family, member A1)
Ortholog Status:The human GeneID 216 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M74570
Note:Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains
Dataset Information
Phenotype:Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013467.3NP_038495.2NC_000085.5 range: 20676471..20717951
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0001758retinal dehydrogenase activityMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:00040283-chloroallyl aldehyde dehydrogenase activityMolecular FunctionIDA (12610736)
GO:0008152metabolic processBiological ProcessIEA
GO:0002072optic cup morphogenesis involved in camera-type eye developmentBiological ProcessIGI (16611695)
GO:0042573retinoic acid metabolic processBiological ProcessIGI (16207763)
GO:0042573retinoic acid metabolic processBiological ProcessIMP (12808103|16207763)
GO:0043065positive regulation of apoptosisBiological ProcessIGI (16207763|16611695)
GO:0048048embryonic eye morphogenesisBiological ProcessIGI (16207763|16611695)
Other Database Cross Links
NCBI Entrez Gene:11668