ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Aldh1a1

Full Name:

aldehyde dehydrogenase family 1, subfamily A1

Alias:

Ahd-2|Ahd2|Aldh1|Aldh1a2|E1|Raldh1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

19 B|19 12.0 cM

Physical Location:

20676471-20717951 on NC_000085.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 216 Symbol (Name): ALDH1A1 (aldehyde dehydrogenase 1 family, member A1)

Ortholog Status:

The human GeneID 216 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M74570
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013467.3	NP_038495.2	NC_000085.5 range: 20676471..20717951

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0001758	retinal dehydrogenase activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity	Molecular Function	IDA (12610736)
GO:0008152	metabolic process	Biological Process	IEA
GO:0002072	optic cup morphogenesis involved in camera-type eye development	Biological Process	IGI (16611695)
GO:0042573	retinoic acid metabolic process	Biological Process	IGI (16207763)
GO:0042573	retinoic acid metabolic process	Biological Process	IMP (12808103\|16207763)
GO:0043065	positive regulation of apoptosis	Biological Process	IGI (16207763\|16611695)
GO:0048048	embryonic eye morphogenesis	Biological Process	IGI (16207763\|16611695)