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Gene Information
Gene ID:116681
Full Name:discs, large (Drosophila) homolog-associated protein 2
Organism:Rattus norvegicus (Rat)
Genetic Location:16q12.5
Physical Location:79613015-80332282 on NC_005115.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 9228    Symbol (Name): DLGAP2 (discs, large (Drosophila) homolog-associated protein 2)
Ortholog Status:The human GeneID 9228 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Dlgap2
Fold Change:1.15
P Value:0.002
Note:Differential expression between ethanol and saccharin groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053901.1NP_446353.1NC_005115.2 range: 79613015..80332282, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045211postsynaptic membraneCellular ComponentNAS (12552131)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0005883neurofilamentCellular ComponentNAS
GO:0005886plasma membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0030425dendriteCellular ComponentIDA (12552131)
GO:0030054cell junctionCellular ComponentIEA
GO:0019904protein domain specific bindingMolecular FunctionIDA (9115257)
GO:0005515protein bindingMolecular FunctionNAS
GO:0004385guanylate kinase activityMolecular FunctionNAS (12552131)
GO:0007270nerve-nerve synaptic transmissionBiological ProcessNAS
GO:0007267cell-cell signalingBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:116681