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Gene Information
Gene ID:116744
Symbol:Lpar1
Full Name:lysophosphatidic acid receptor 1
Alias:Edg2|MGC105279
Organism:Rattus norvegicus (Rat)
Chromosome:5
Genetic Location:5q24
Physical Location:76449471-76571457 on NC_005104.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1902    Symbol (Name): LPAR1 (lysophosphatidic acid receptor 1)
Ortholog Status:The human GeneID 1902 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Edg2
Fold Change:1.16
P Value:0.005
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053936.3NP_446388.1NC_005104.2 range: 76449471..76571457, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0001619lysosphingolipid and lysophosphatidic acid receptor activityMolecular FunctionIDA (16242672)
GO:0005543phospholipid bindingMolecular FunctionIMP (16504475)
GO:0005543phospholipid bindingMolecular FunctionIDA (16242672)
GO:0001619lysosphingolipid and lysophosphatidic acid receptor activityMolecular FunctionIEA
GO:0001619lysosphingolipid and lysophosphatidic acid receptor activityMolecular FunctionIMP (16504475)
GO:0001965G-protein alpha-subunit bindingMolecular FunctionIMP (16504475)
GO:0004872receptor activityMolecular FunctionIEA
GO:0004930G-protein coupled receptor activityMolecular FunctionTAS (12123830)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIMP (16504475)
GO:0007165signal transductionBiological ProcessIEA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeBiological ProcessIEA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeBiological ProcessISS
GO:0051482elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)Biological ProcessIDA (16242672)
Other Database Cross Links
NCBI Entrez Gene:116744
RGD:620563
Ensembl:ENSRNOG00000013656
dbSNP:Lpar1