ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Lpar1

Full Name:

lysophosphatidic acid receptor 1

Alias:

Edg2|MGC105279

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

5q24

Physical Location:

76449471-76571457 on NC_005104.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1902 Symbol (Name): LPAR1 (lysophosphatidic acid receptor 1)

Ortholog Status:

The human GeneID 1902 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Edg2
Fold Change:		1.16
P Value:		0.005
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053936.3	NP_446388.1	NC_005104.2 range: 76449471..76571457, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0001619	lysosphingolipid and lysophosphatidic acid receptor activity	Molecular Function	IDA (16242672)
GO:0005543	phospholipid binding	Molecular Function	IMP (16504475)
GO:0005543	phospholipid binding	Molecular Function	IDA (16242672)
GO:0001619	lysosphingolipid and lysophosphatidic acid receptor activity	Molecular Function	IEA
GO:0001619	lysosphingolipid and lysophosphatidic acid receptor activity	Molecular Function	IMP (16504475)
GO:0001965	G-protein alpha-subunit binding	Molecular Function	IMP (16504475)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS (12123830)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IMP (16504475)
GO:0007165	signal transduction	Biological Process	IEA
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IEA
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	ISS
GO:0051482	elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)	Biological Process	IDA (16242672)