ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Alox12b

Full Name:

arachidonate 12-lipoxygenase, 12R type

Alias:

Aloxe2|MGC130560|e-LOX2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B3|11 37.0 cM

Physical Location:

68970573-68983292 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 242 Symbol (Name): ALOX12B (arachidonate 12-lipoxygenase, 12R type)

Ortholog Status:

The human GeneID 242 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Alox12b
Original ID2:		X98475

Gene Information

Original ID1:		---
Original ID2:		Y14334

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore4	Alcohol-induced Loss of Righting Reflex	11		36-42 (cM)	6.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009659.2	NP_033789.1	NC_000077.5 range: 68970573..68983292

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0016165	lipoxygenase activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006691	leukotriene metabolic process	Biological Process	IEA
GO:0019370	leukotriene biosynthetic process	Biological Process	IEA