| Gene Information |
| Gene ID: | | 116967 |
| Symbol: | | Magt1 |
| Full Name: | | magnesium transporter 1 |
| Alias: | | Iag2 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | X |
| Genetic Location: | | Xq31 |
| Physical Location: | | 94095542-94133656 on NC_005120.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 84061 Symbol (Name): MAGT1 (magnesium transporter 1) |
| Ortholog Status: | | The human GeneID 84061 is also in human dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Rn.43578 | | Original ID2: | | IAG2 | | Fold Change: | | 1.7 | | P Value: | | 0.00125 | | Note: | | higher levels in hippocampus of iP than iNP rats |
| | Dataset Information | | Name: | | 15660665 | | Method: | | Microarray | | Tissue: | | Hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed | | Summary: | | The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01). |
| | Gene Information | | Original ID1: | | Iag2 | | Fold Change: | | 1.31 | | Tissue: | | Hippocampus |
| | Dataset Information | | Name: | | 17517326 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed | | Summary: | | The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005783 | endoplasmic reticulum | Cellular Component | IEA | |
| GO:0008250 | oligosaccharyl transferase complex | Cellular Component | ISS | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0016021 | integral to membrane | Cellular Component | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 116967 |
| RGD: | | 620094 |
| Ensembl: | | ENSRNOG00000002519 |
| dbSNP: | | Magt1 |
