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Gene Information
Gene ID:117018
Full Name:potassium voltage-gated channel, subfamily H (eag-related), member 2
Organism:Rattus norvegicus (Rat)
Genetic Location:4q11
Physical Location:6192643-6224284 on NC_005103.2
Gene Type:protein-coding
Human Ortholog:GeneID: 3757    Symbol (Name): KCNH2 (potassium voltage-gated channel, subfamily H (eag-related), member 2)
Ortholog Status:The human GeneID 3757 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Kcnh2
Fold Change:-1.14
P Value:0.009
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053949.1NP_446401.1NC_005103.2 range: 6192643..6224284
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentIDA (11804849)
GO:0005886plasma membraneCellular ComponentISS
GO:0005635nuclear envelopeCellular ComponentISS
GO:0030955potassium ion bindingMolecular FunctionIEA
GO:0000155two-component sensor activityMolecular FunctionIEA
GO:0005267potassium channel activityMolecular FunctionIDA (11804849)
GO:0005249voltage-gated potassium channel activityMolecular FunctionIEA
GO:0005249voltage-gated potassium channel activityMolecular FunctionIDA (15677682)
GO:0005244voltage-gated ion channel activityMolecular FunctionIEA
GO:0005242inward rectifier potassium channel activityMolecular FunctionIDA (15677682)
GO:0005216ion channel activityMolecular FunctionIDA (11804849)
GO:0005216ion channel activityMolecular FunctionIEA
GO:0000160two-component signal transduction system (phosphorelay)Biological ProcessIEA
GO:0006813potassium ion transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0042391regulation of membrane potentialBiological ProcessIDA (11804849)
Other Database Cross Links
NCBI Entrez Gene:117018