ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Kcnh2

Full Name:

potassium voltage-gated channel, subfamily H (eag-related), member 2

Alias:

ERG1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

4q11

Physical Location:

6192643-6224284 on NC_005103.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3757 Symbol (Name): KCNH2 (potassium voltage-gated channel, subfamily H (eag-related), member 2)

Ortholog Status:

The human GeneID 3757 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Kcnh2
Fold Change:		-1.14
P Value:		0.009
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053949.1	NP_446401.1	NC_005103.2 range: 6192643..6224284

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	IDA (11804849)
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0005635	nuclear envelope	Cellular Component	ISS
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0000155	two-component sensor activity	Molecular Function	IEA
GO:0005267	potassium channel activity	Molecular Function	IDA (11804849)
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IDA (15677682)
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0005242	inward rectifier potassium channel activity	Molecular Function	IDA (15677682)
GO:0005216	ion channel activity	Molecular Function	IDA (11804849)
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0000160	two-component signal transduction system (phosphorelay)	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0042391	regulation of membrane potential	Biological Process	IDA (11804849)