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Gene Information
Gene ID:117038
Full Name:metallothionein 3
Organism:Rattus norvegicus (Rat)
Genetic Location:19p12
Physical Location:11284553-11286401 on NC_005118.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 4504    Symbol (Name): MT3 (metallothionein 3)
Ortholog Status:The human GeneID 4504 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Mt3
Fold Change:1.14
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053968.2NP_446420.1NC_005118.2 range: 11284553..11286401, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0008021synaptic vesicleCellular ComponentISS
GO:0051536iron-sulfur cluster bindingMolecular FunctionIEA
GO:0005507copper ion bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionISS
GO:0009055electron carrier activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionISS
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0050774negative regulation of dendrite morphogenesisBiological ProcessNAS
GO:0050768negative regulation of neurogenesisBiological ProcessISS
GO:0030308negative regulation of cell growthBiological ProcessNAS
GO:0019430removal of superoxide radicalsBiological ProcessISS
GO:0006875cellular metal ion homeostasisBiological ProcessISS
GO:0006875cellular metal ion homeostasisBiological ProcessIEA
GO:0001666response to hypoxiaBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:117038