ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mt3

Full Name:

metallothionein 3

Alias:

GIF|Mt-3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

19p12

Physical Location:

11284553-11286401 on NC_005118.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4504 Symbol (Name): MT3 (metallothionein 3)

Ortholog Status:

The human GeneID 4504 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mt3
Fold Change:		1.14
P Value:		0.003
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053968.2	NP_446420.1	NC_005118.2 range: 11284553..11286401, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008021	synaptic vesicle	Cellular Component	ISS
GO:0051536	iron-sulfur cluster binding	Molecular Function	IEA
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	ISS
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	ISS
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0050774	negative regulation of dendrite morphogenesis	Biological Process	NAS
GO:0050768	negative regulation of neurogenesis	Biological Process	ISS
GO:0030308	negative regulation of cell growth	Biological Process	NAS
GO:0019430	removal of superoxide radicals	Biological Process	ISS
GO:0006875	cellular metal ion homeostasis	Biological Process	ISS
GO:0006875	cellular metal ion homeostasis	Biological Process	IEA
GO:0001666	response to hypoxia	Biological Process	ISS