ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cand1

Full Name:

cullin associated and neddylation disassociated 1

Alias:

Tip120|Tip120A

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q22

Physical Location:

58461204-58499093 on NC_005106.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 55832 Symbol (Name): CAND1 (cullin-associated and neddylation-dissociated 1)

Ortholog Status:

The human GeneID 55832 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.32934
Original ID2:		Tip120A
Fold Change:		1.2
P Value:		0.00888
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_054004.1	NP_446456.1	NC_005106.2 range: 58461204..58499093, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000151	ubiquitin ligase complex	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IDA (8954946)
GO:0005634	nucleus	Cellular Component	ISS
GO:0017025	TATA-binding protein binding	Molecular Function	IDA (8954946)
GO:0016563	transcription activator activity	Molecular Function	IDA
GO:0005515	protein binding	Molecular Function	ISS
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0016567	protein ubiquitination	Biological Process	ISS
GO:0030154	cell differentiation	Biological Process	ISS
GO:0043086	negative regulation of catalytic activity	Biological Process	ISS
GO:0045899	positive regulation of transcriptional preinitiation complex assembly	Biological Process	IDA