ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cflar

Full Name:

CASP8 and FADD-like apoptosis regulator

Alias:

Flip|MGC108616

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

9q31

Physical Location:

57309835-57361453 on NC_005108.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8837 Symbol (Name): CFLAR (CASP8 and FADD-like apoptosis regulator)

Ortholog Status:

The human GeneID 8837 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cflar
Fold Change:		1.27
P Value:		0.001
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Cflar
Fold Change:		1.29
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0004871	signal transducer activity	Molecular Function	ISS
GO:0030693	caspase activity	Molecular Function	IEA
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	IEA
GO:0006916	anti-apoptosis	Biological Process	IMP (12135878)
GO:0042981	regulation of apoptosis	Biological Process	IEA
GO:0043066	negative regulation of apoptosis	Biological Process	ISS
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	ISS
GO:0043154	negative regulation of caspase activity	Biological Process	ISS