ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ank1

Full Name:

ankyrin 1, erythroid

Alias:

Ank-1|nb

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 A2|8 9.5 cM

Physical Location:

24168746-24260967 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 286 Symbol (Name): ANK1 (ankyrin 1, erythrocytic)

Ortholog Status:

The human GeneID 286 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ank1
Original ID2:		U76758

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031158.2	NP_112435.2	NC_000074.5 range: 24168746..24260967

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016529	sarcoplasmic reticulum	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0015672	monovalent inorganic cation transport	Biological Process	IMP (7492791)
GO:0048821	erythrocyte development	Biological Process	IMP (2139228)