ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ank3

Full Name:

ankyrin 3, epithelial

Alias:

2900054D09Rik|AI314020|Ank-3|AnkG|Ankyrin-3|MGC14049

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

10 B5.3|10 38.0 cM

Physical Location:

68996455-69490183 on NC_000076.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 288 Symbol (Name): ANK3 (ankyrin 3, node of Ranvier (ankyrin G))

Ortholog Status:

The human GeneID 288 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ank3
Original ID2:		L40632

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030424	axon	Cellular Component	IDA (15479642)
GO:0045202	synapse	Cellular Component	IDA (10995443)
GO:0005515	protein binding	Molecular Function	IPI (15823567)
GO:0005515	protein binding	Molecular Function	ISO
GO:0007411	axon guidance	Biological Process	IMP (15479642)
GO:0050808	synapse organization and biogenesis	Biological Process	IMP (15479642)