ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

AP1S1

Full Name:

adaptor-related protein complex 1, sigma 1 subunit

Alias:

AP19|CLAPS1|FLJ92436|SIGMA1A|WUGSC:H_DJ0747G18.2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

7q22.1

Physical Location:

100584405-100591276 on NC_000007.12

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI936759
Fold Change:		2.14

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (15569716)
GO:0005905	coated pit	Cellular Component	IEA
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	IEA
GO:0030121	AP-1 adaptor complex	Cellular Component	TAS (9733768)
GO:0016020	membrane	Cellular Component	IEA
GO:0030117	membrane coat	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0006898	receptor-mediated endocytosis	Biological Process	TAS (9733768)