ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Irbp

Alias:

CG5247|DmBlm|DmKu70|IRBP/Ku70|Ku|Ku70|MUS309|YPF1|YPF1beta|Ypf1b|dp70|p70

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

86E4-86E4

Physical Location:

7235770-7238169 on NT_033777.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2547 Symbol (Name): XRCC6 (X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa))

Ortholog Status:

The human GeneID 2547 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Irbp
P Value:		5.44E-03
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_080512.2	NP_536773.1	NT_033777.2 range: 7235770..7238169

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043564	Ku70:Ku80 complex	Cellular Component	IDA (8157678)
GO:0005958	DNA-dependent protein kinase complex	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	NAS
GO:0046982	protein heterodimerization activity	Molecular Function	IDA (8157678)
GO:0004677	DNA-dependent protein kinase activity	Molecular Function	NAS
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function	NAS
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	NAS
GO:0003677	DNA binding	Molecular Function	ISS (7809101)
GO:0003677	DNA binding	Molecular Function	IDA (8663250)
GO:0003677	DNA binding	Molecular Function	IDA (7809101\|8157678)
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	IEA
GO:0000723	telomere maintenance	Biological Process	IMP (15781709)