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Gene Information
Gene ID:117559
Symbol:Sv2a
Full Name:synaptic vesicle glycoprotein 2a
Alias:MGC105346|Sv2
Organism:Rattus norvegicus (Rat)
Chromosome:2
Genetic Location:2q34
Physical Location:190985434-191000811 on NC_005101.2
Gene Type:protein-coding
Human Ortholog:GeneID: 9900    Symbol (Name): SV2A (synaptic vesicle glycoprotein 2A)
Ortholog Status:The human GeneID 9900 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Sv2a
Fold Change:1.22
P Value:0.001
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Sv2a
Fold Change:1.18
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057210.2NP_476558.2NC_005101.2 range: 190985434..191000811
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045202synapseCellular ComponentIEA
GO:0031410cytoplasmic vesicleCellular ComponentIEA
GO:0030672synaptic vesicle membraneCellular ComponentIDA (1519064)
GO:0030054cell junctionCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIDA (1519064)
GO:0016020membraneCellular ComponentIEA
GO:0008021synaptic vesicleCellular ComponentISS
GO:0005783endoplasmic reticulumCellular ComponentISS
GO:0005515protein bindingMolecular FunctionIPI
GO:0005215transporter activityMolecular FunctionTAS (1519064)
GO:0005215transporter activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0006874cellular calcium ion homeostasisBiological ProcessISS
GO:0006836neurotransmitter transportBiological ProcessTAS (1519064)
GO:0006836neurotransmitter transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:117559
RGD:619715
Ensembl:ENSRNOG00000021182
dbSNP:Sv2a