Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:117596
Full Name:ATPase, H transporting, lysosomal V1 subunit B2
Organism:Rattus norvegicus (Rat)
Genetic Location:16p14
Physical Location:22320424-22344444 on NC_005115.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 526    Symbol (Name): ATP6V1B2 (ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2)
Ortholog Status:The human GeneID 526 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Atp6v1b2
Fold Change:-1.16
P Value:0.009
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057213.2NP_476561.1NC_005115.2 range: 22320424..22344444, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0042470melanosomeCellular ComponentIEA
GO:0016469proton-transporting two-sector ATPase complexCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIDA (15013950)
GO:0016020membraneCellular ComponentIEA
GO:0046961hydrogen ion transporting ATPase activity, rotational mechanismMolecular FunctionIEA
GO:0046933hydrogen ion transporting ATP synthase activity, rotational mechanismMolecular FunctionIEA
GO:0008553hydrogen-exporting ATPase activity, phosphorylative mechanismMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0006811ion transportBiological ProcessIEA
GO:0030641regulation of cellular pHBiological ProcessTAS (15013950)
GO:0007035vacuolar acidificationBiological ProcessTAS (15013950)
GO:0015986ATP synthesis coupled proton transportBiological ProcessIEA
GO:0015988energy coupled proton transport, against electrochemical gradientBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:117596