ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Atp6v1b2

Full Name:

ATPase, H transporting, lysosomal V1 subunit B2

Alias:

Atp6b1b2|Atp6b2|Vatb

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

16p14

Physical Location:

22320424-22344444 on NC_005115.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 526 Symbol (Name): ATP6V1B2 (ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2)

Ortholog Status:

The human GeneID 526 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Atp6v1b2
Fold Change:		-1.16
P Value:		0.009
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_057213.2	NP_476561.1	NC_005115.2 range: 22320424..22344444, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0042470	melanosome	Cellular Component	IEA
GO:0016469	proton-transporting two-sector ATPase complex	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IDA (15013950)
GO:0016020	membrane	Cellular Component	IEA
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	Molecular Function	IEA
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	Molecular Function	IEA
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0030641	regulation of cellular pH	Biological Process	TAS (15013950)
GO:0007035	vacuolar acidification	Biological Process	TAS (15013950)
GO:0015986	ATP synthesis coupled proton transport	Biological Process	IEA
GO:0015988	energy coupled proton transport, against electrochemical gradient	Biological Process	IEA