ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Apbb1

Full Name:

amyloid beta (A4) precursor protein-binding, family B, member 1

Alias:

Fe65|Rir

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

7 E3|7 46.6 cM

Physical Location:

112706997-112730048 on NC_000073.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 322 Symbol (Name): APBB1 (amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65))

Ortholog Status:

The human GeneID 322 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Apbb1
Original ID2:		AI839886

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009685.2	NP_033815.1	NC_000073.5 range: 112706997..112730048, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (12089154)
GO:0001540	beta-amyloid binding	Molecular Function	IDA (8894693)
GO:0035035	histone acetyltransferase binding	Molecular Function	NAS (12089154)
GO:0005515	protein binding	Molecular Function	IPI (8894693\|9407065\|16301330)
GO:0008134	transcription factor binding	Molecular Function	IDA (12089154)
GO:0045449	regulation of transcription	Biological Process	IDA (12089154)
GO:0045749	negative regulation of S phase of mitotic cell cycle	Biological Process	IDA (12089154)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15944124)
GO:0050760	negative regulation of thymidylate synthase biosynthetic process	Biological Process	IDA (12089154)
GO:0030308	negative regulation of cell growth	Biological Process	IDA (12089154)
GO:0030198	extracellular matrix organization and biogenesis	Biological Process	IGI (16407979)
GO:0030048	actin filament-based movement	Biological Process	NAS (12089154)
GO:0008542	visual learning	Biological Process	IMP (14689444)
GO:0007411	axon guidance	Biological Process	IGI (16407979)
GO:0007050	cell cycle arrest	Biological Process	IDA (12089154)
GO:0001764	neuron migration	Biological Process	IGI (16407979)
GO:0050821	protein stabilization	Biological Process	NAS (11544248)