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Gene Information
Gene ID:11785
Symbol:Apbb1
Full Name:amyloid beta (A4) precursor protein-binding, family B, member 1
Alias:Fe65|Rir
Organism:Mus musculus (Mouse)
Chromosome:7
Genetic Location:7 E3|7 46.6 cM
Physical Location:112706997-112730048 on NC_000073.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 322    Symbol (Name): APBB1 (amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65))
Ortholog Status:The human GeneID 322 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Apbb1
Original ID2:AI839886
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009685.2NP_033815.1NC_000073.5 range: 112706997..112730048, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (12089154)
GO:0001540beta-amyloid bindingMolecular FunctionIDA (8894693)
GO:0035035histone acetyltransferase bindingMolecular FunctionNAS (12089154)
GO:0005515protein bindingMolecular FunctionIPI (8894693|9407065|16301330)
GO:0008134transcription factor bindingMolecular FunctionIDA (12089154)
GO:0045449regulation of transcriptionBiological ProcessIDA (12089154)
GO:0045749negative regulation of S phase of mitotic cell cycleBiological ProcessIDA (12089154)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIGI (15944124)
GO:0050760negative regulation of thymidylate synthase biosynthetic processBiological ProcessIDA (12089154)
GO:0030308negative regulation of cell growthBiological ProcessIDA (12089154)
GO:0030198extracellular matrix organization and biogenesisBiological ProcessIGI (16407979)
GO:0030048actin filament-based movementBiological ProcessNAS (12089154)
GO:0008542visual learningBiological ProcessIMP (14689444)
GO:0007411axon guidanceBiological ProcessIGI (16407979)
GO:0007050cell cycle arrestBiological ProcessIDA (12089154)
GO:0001764neuron migrationBiological ProcessIGI (16407979)
GO:0050821protein stabilizationBiological ProcessNAS (11544248)
Other Database Cross Links
NCBI Entrez Gene:11785
MGI:
Ensembl:ENSMUSG00000037032
dbSNP:Apbb1
AceView:Apbb1