ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

11806

Symbol:

Apoa1

Full Name:

apolipoprotein A-I

Alias:

Alp-1|Apoa-1|Brp-14|Ltw-1|Lvtw-1|MGC102525|Sep-1|Sep-2|Sep2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 A2-A4|9 27.0 cM

Physical Location:

46036792-46038548 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 335 Symbol (Name): APOA1 (apolipoprotein A-I)

Ortholog Status:

The human GeneID 335 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap5q	Alcohol Preference Drinking	9	25	10-35 (cM)	4.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009692.3	NP_033822.2	NC_000075.5 range: 46036792..46038548

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005615	extracellular space	Cellular Component	IDA (1596514\|6403543\|7751823\|7798939\|9186920\|9275209\|9300780\|9507992\|10357841\|11744719\|12859204\|14595002)
GO:0005576	extracellular region	Cellular Component	IDA (15793583)
GO:0005319	lipid transporter activity	Molecular Function	IMP (1496008)
GO:0008289	lipid binding	Molecular Function	IDA (8049247)
GO:0042802	identical protein binding	Molecular Function	IPI (8049247\|11744719)
GO:0017127	cholesterol transporter activity	Molecular Function	IDA (15269218)
GO:0008034	lipoprotein binding	Molecular Function	IDA (8049247)
GO:0008035	high-density lipoprotein binding	Molecular Function	IDA (11744719\|14595002)
GO:0005319	lipid transporter activity	Molecular Function	IDA (11744719)
GO:0005515	protein binding	Molecular Function	ISS (11991719)
GO:0005515	protein binding	Molecular Function	IPI (16204232)
GO:0030325	adrenal gland development	Biological Process	IMP (8647961)
GO:0030301	cholesterol transport	Biological Process	ISS (10559507)
GO:0001932	regulation of protein amino acid phosphorylation	Biological Process	IDA (12869555)
GO:0030301	cholesterol transport	Biological Process	IMP (7751823\|8798380\|9507992\|9684752)
GO:0031103	axon regeneration	Biological Process	IGI (7798939)
GO:0033344	cholesterol efflux	Biological Process	IDA (9186920\|11744719\|12869555\|15269218)
GO:0033344	cholesterol efflux	Biological Process	IMP (9275209)
GO:0042157	lipoprotein metabolic process	Biological Process	IEA
GO:0042158	lipoprotein biosynthetic process	Biological Process	IGI (14595002)
GO:0042158	lipoprotein biosynthetic process	Biological Process	IMP (16245952)
GO:0043534	blood vessel endothelial cell migration	Biological Process	IMP (16339487)
GO:0051346	negative regulation of hydrolase activity	Biological Process	IGI (15995171)
GO:0030301	cholesterol transport	Biological Process	IDA (9300780)
GO:0030300	regulation of cholesterol absorption	Biological Process	IDA (10073953)
GO:0001935	endothelial cell proliferation	Biological Process	IMP (16339487)
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0006644	phospholipid metabolic process	Biological Process	IMP (9795222)
GO:0006695	cholesterol biosynthetic process	Biological Process	IMP (8647961)
GO:0006810	transport	Biological Process	IEA
GO:0006869	lipid transport	Biological Process	IEA
GO:0008104	protein localization	Biological Process	IMP (9325076)
GO:0008202	steroid metabolic process	Biological Process	IEA
GO:0008203	cholesterol metabolic process	Biological Process	IGI (15995171)
GO:0008203	cholesterol metabolic process	Biological Process	IMP (7751823\|9327769\|9795222\|10357841\|15466405\|17071966)
GO:0008211	glucocorticoid metabolic process	Biological Process	IMP (8647961)
GO:0019915	sequestering of lipid	Biological Process	IMP (8647961)
GO:0051347	positive regulation of transferase activity	Biological Process	IMP (16245952)