ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

335

Symbol:

APOA1

Full Name:

apolipoprotein A-I

Alias:

MGC117399

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

11q23-q24

Physical Location:

116211678-116213547 on NC_000011.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 11806 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

X00566

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Information

Original ID1:

APOA1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000039.1	NP_000030.1	NC_000011.8 range: 116211678..116213547, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	IDA (15464323)
GO:0031410	cytoplasmic vesicle	Cellular Component	IDA (14703508)
GO:0005576	extracellular region	Cellular Component	EXP (4345202\|12692552)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0030139	endocytic vesicle	Cellular Component	IDA (14747463)
GO:0005788	endoplasmic reticulum lumen	Cellular Component	EXP (12692552)
GO:0015485	cholesterol binding	Molecular Function	IDA (15464323)
GO:0017127	cholesterol transporter activity	Molecular Function	IMP (15464323)
GO:0001540	beta-amyloid binding	Molecular Function	IDA (11297421)
GO:0034191	apolipoprotein A-I receptor binding	Molecular Function	IPI (16443932)
GO:0042802	identical protein binding	Molecular Function	IPI (8049247)
GO:0008289	lipid binding	Molecular Function	IEA
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	Molecular Function	IDA (4335615)
GO:0005543	phospholipid binding	Molecular Function	IDA (12810715)
GO:0005319	lipid transporter activity	Molecular Function	IEA
GO:0043691	reverse cholesterol transport	Biological Process	IMP (15464323)
GO:0002740	negative regulation of cytokine secretion during immune response	Biological Process	IDA (12458630)
GO:0050713	negative regulation of interleukin-1 beta secretion	Biological Process	IDA (12458630)
GO:0050821	protein stabilization	Biological Process	IDA (17655203)
GO:0042158	lipoprotein biosynthetic process	Biological Process	IDA (4335615)
GO:0042157	lipoprotein metabolic process	Biological Process	IEA
GO:0042632	cholesterol homeostasis	Biological Process	IMP (15464323)
GO:0033700	phospholipid efflux	Biological Process	IDA (11162594\|14703508)
GO:0033344	cholesterol efflux	Biological Process	IDA (11162594\|14703508\|16443932)
GO:0032488	Cdc42 protein signal transduction	Biological Process	IDA (16443932)
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0006656	phosphatidylcholine biosynthetic process	Biological Process	IDA (4335615)
GO:0006869	lipid transport	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IDA (16443932)
GO:0008203	cholesterol metabolic process	Biological Process	IEA
GO:0008202	steroid metabolic process	Biological Process	IEA