ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CLCN4

Full Name:

chloride channel 4

Alias:

CLC4|ClC-4|ClC-4A|MGC163150

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

Xp22.3

Physical Location:

10084984-10165699 on NC_000023.9

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 60586 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001830.3	NP_001821.2	NC_000023.9 range: 10084984..10165699

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	NR
GO:0005887	integral to plasma membrane	Cellular Component	NR
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0031404	chloride ion binding	Molecular Function	IEA
GO:0005247	voltage-gated chloride channel activity	Molecular Function	TAS (8069296)
GO:0005247	voltage-gated chloride channel activity	Molecular Function	IEA
GO:0006821	chloride transport	Biological Process	IDA (10564087)
GO:0006821	chloride transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA