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Gene Information
Gene ID:60586
Full Name:chloride channel 4-2
Organism:Rattus norvegicus (Rat)
Genetic Location:Xq21
Physical Location:44355647-44419523 on NC_005120.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1183    Symbol (Name): CLCN4 (chloride channel 4)
Ortholog Status:The human GeneID 1183 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Clcn4-2
Fold Change:-1.15
P Value:0.005
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_022198.2NP_071534.2NC_005120.2 range: 44355647..44419523
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005247voltage-gated chloride channel activityMolecular FunctionIEA
GO:0006821chloride transportBiological ProcessIEA
GO:0006821chloride transportBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:60586