ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rhoc

Full Name:

ras homolog gene family, member C

Alias:

AI324259|Arh9|Arhc

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

3 F2.2

Physical Location:

104591969-104597376 on NC_000069.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 389 Symbol (Name): RHOC (ras homolog gene family, member C)

Ortholog Status:

The human GeneID 389 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rhoc
Original ID2:		X80638

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007484.2	NP_031510.2	NC_000069.5 range: 104591969..104597376

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (15093731)
GO:0005886	plasma membrane	Cellular Component	IDA (15093731)
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (8543060)
GO:0005525	GTP binding	Molecular Function	IEA
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA