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Gene Information
Gene ID:11853
Full Name:ras homolog gene family, member C
Organism:Mus musculus (Mouse)
Genetic Location:3 F2.2
Physical Location:104591969-104597376 on NC_000069.5
Gene Type:protein-coding
Human Ortholog:GeneID: 389    Symbol (Name): RHOC (ras homolog gene family, member C)
Ortholog Status:The human GeneID 389 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rhoc
Original ID2:X80638
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007484.2NP_031510.2NC_000069.5 range: 104591969..104597376
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005634nucleusCellular ComponentIDA (15093731)
GO:0005886plasma membraneCellular ComponentIDA (15093731)
GO:0016020membraneCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (8543060)
GO:0005525GTP bindingMolecular FunctionIEA
GO:0007264small GTPase mediated signal transductionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:11853