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Gene Information
Gene ID:11908
Full Name:activating transcription factor 1
Organism:Mus musculus (Mouse)
Physical Location:100058289-100091678 on NC_000081.5
Gene Type:protein-coding
Human Ortholog:GeneID: 466    Symbol (Name): ATF1 (activating transcription factor 1)
Ortholog Status:The human GeneID 466 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Atf1
Fold Change:2
Note:More highly expressed in ISS
Dataset Information
Method:Microarray and QTL
Phenotype:Ethanol sensitivity
Publication:MacLaren et al. Mamm Genome. (2006) Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. PubMed
Summary:The Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) mouse strains have a 16-fold difference in duration of loss of the righting response (LORR) following administration of a sedative dose of ethanol. Four quantitative trait loci (QTLs) have been mapped in these strains for this trait. Genome-wide expression profiling in cerebellum was used here to identify candidate genes for regulatory region differences in these two strains. Fifteen differentially expressed genes were found that map to the QTL regions.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007497.3NP_031523.3NC_000081.5 range: 100058289..100091678
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS (8798441)
GO:0005667transcription factor complexCellular ComponentIDA (11354513)
GO:0003677DNA bindingMolecular FunctionIDA (11354513)
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0046983protein dimerization activityMolecular FunctionIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:11908