ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Atf1

Full Name:

activating transcription factor 1

Organism:

Mus musculus (Mouse)

Chromosome:

Physical Location:

100058289-100091678 on NC_000081.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 466 Symbol (Name): ATF1 (activating transcription factor 1)

Ortholog Status:

The human GeneID 466 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		16465594
Method:		Microarray and QTL
Tissue:		Cerebellum
Phenotype:		Ethanol sensitivity
Publication:		MacLaren et al. Mamm Genome. (2006) Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. PubMed
Summary:		The Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) mouse strains have a 16-fold difference in duration of loss of the righting response (LORR) following administration of a sedative dose of ethanol. Four quantitative trait loci (QTLs) have been mapped in these strains for this trait. Genome-wide expression profiling in cerebellum was used here to identify candidate genes for regulatory region differences in these two strains. Fifteen differentially expressed genes were found that map to the QTL regions.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007497.3	NP_031523.3	NC_000081.5 range: 100058289..100091678

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS (8798441)
GO:0005667	transcription factor complex	Cellular Component	IDA (11354513)
GO:0003677	DNA binding	Molecular Function	IDA (11354513)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA