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Dataset Description
  • Dataset Name: 16465594
  • Species: Mouse
  • Method: Microarray and QTL
  • No. of Genes: 15
  • Tissue: Cerebellum
  • Phenotype: Ethanol sensitivity
  • Publication: MacLaren et al. Mamm Genome. (2006) Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. PubMed
  • Dataset Summary: The Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) mouse strains have a 16-fold difference in duration of loss of the righting response (LORR) following administration of a sedative dose of ethanol. Four quantitative trait loci (QTLs) have been mapped in these strains for this trait. Genome-wide expression profiling in cerebellum was used here to identify candidate genes for regulatory region differences in these two strains. Fifteen differentially expressed genes were found that map to the QTL regions.

    Gene list of this dataset (15 genes)
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    18549Pcsk2proprotein convertase subtilisin/kexin type 22 F3-H2|2 81.4 cMPcsk2 
    30805Slc22a4solute carrier family 22 (organic cation transporter), member 411 B1.3|11 28.0 cMSlc22a4 
    338367Myo1dmyosin ID11 B5|11 46.0 cMMyo1d 
    68588Cthrc1collagen triple helix repeat containing 115 CCthrc1 
    16691Krt8keratin 815 F3|15 58.86 cMKrt2-8 
    107753Lgals2lectin, galactose-binding, soluble 215 E1Lgals2 
    170729Scrt1scratch homolog 1, zinc finger protein (Drosophila)15 E1Scrt1 
    22596Xrcc5X-ray repair complementing defective repair in Chinese hamster cells 51 E|1 42.0 cMXrcc5 
    215653Rassf2Ras association (RalGDS/AF-6) domain family member 22 F2Rassf2 
    13591Ebf1early B-cell factor 111 B1.1|11 20.0 cMEbf1 
    55943Stx8syntaxin 811 B3Stx8 
    76281Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 311 B4Tax1bp3 
    21927Tnfaip1tumor necrosis factor, alpha-induced protein 1 (endothelial)11 B5|11 45.1 cMTnfaip1 
    11908Atf1activating transcription factor 1-Atf1