ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ebf1

Full Name:

early B-cell factor 1

Alias:

9830166E18Rik|AW990631|Ebf|O/E-1|Olf-1|Olf1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B1.1|11 20.0 cM

Physical Location:

44431635-44818676 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1879 Symbol (Name): EBF1 (early B-cell factor 1)

Ortholog Status:

The human GeneID 1879 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		16465594
Method:		Microarray and QTL
Tissue:		Cerebellum
Phenotype:		Ethanol sensitivity
Publication:		MacLaren et al. Mamm Genome. (2006) Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. PubMed
Summary:		The Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) mouse strains have a 16-fold difference in duration of loss of the righting response (LORR) following administration of a sedative dose of ethanol. Four quantitative trait loci (QTLs) have been mapped in these strains for this trait. Genome-wide expression profiling in cerebellum was used here to identify candidate genes for regulatory region differences in these two strains. Fifteen differentially expressed genes were found that map to the QTL regions.

QTL Information

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007897.2	NP_031923.1	NC_000077.5 range: 44431635..44818676

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (14594818)
GO:0003677	DNA binding	Molecular Function	IDA (14594818)
GO:0030528	transcription regulator activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS (14594818)
GO:0005515	protein binding	Molecular Function	IPI (12139918)
GO:0003700	transcription factor activity	Molecular Function	IDA (14594818)
GO:0006350	transcription	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0045449	regulation of transcription	Biological Process	IEA
GO:0045941	positive regulation of transcription	Biological Process	IDA (12139918)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA (14594818)