ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tax1bp3

Full Name:

Tax1 (human T-cell leukemia virus type I) binding protein 3

Alias:

1300011C24Rik|TIP-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B4

Physical Location:

72990584-72995547 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 30851 Symbol (Name): TAX1BP3 (Tax1 (human T-cell leukemia virus type I) binding protein 3)

Ortholog Status:

The human GeneID 30851 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		16465594
Method:		Microarray and QTL
Tissue:		Cerebellum
Phenotype:		Ethanol sensitivity
Publication:		MacLaren et al. Mamm Genome. (2006) Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. PubMed
Summary:		The Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) mouse strains have a 16-fold difference in duration of loss of the righting response (LORR) following administration of a sedative dose of ethanol. Four quantitative trait loci (QTLs) have been mapped in these strains for this trait. Genome-wide expression profiling in cerebellum was used here to identify candidate genes for regulatory region differences in these two strains. Fifteen differentially expressed genes were found that map to the QTL regions.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_029564.2	NP_083840.1	NC_000077.5 range: 72990584..72995547

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (12874278)
GO:0005737	cytoplasm	Cellular Component	IDA (12874278)
GO:0005515	protein binding	Molecular Function	IEA
GO:0008013	beta-catenin binding	Molecular Function	IPI (12874278)
GO:0030528	transcription regulator activity	Molecular Function	IMP (12874278)
GO:0008285	negative regulation of cell proliferation	Biological Process	IDA (12874278)
GO:0016055	Wnt receptor signaling pathway	Biological Process	IEA
GO:0030178	negative regulation of Wnt receptor signaling pathway	Biological Process	IDA (12874278)