ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Krt8

Full Name:

keratin 8

Alias:

AA960620|AL022697|AU019895|Card2|EndoA|K8|Krt-2.8|Krt2-8|MGC118110

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 F3|15 58.86 cM

Physical Location:

101827141-101834772 on NC_000081.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3856 Symbol (Name): KRT8 (keratin 8)

Ortholog Status:

The human GeneID 3856 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		16465594
Method:		Microarray and QTL
Tissue:		Cerebellum
Phenotype:		Ethanol sensitivity
Publication:		MacLaren et al. Mamm Genome. (2006) Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. PubMed
Summary:		The Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) mouse strains have a 16-fold difference in duration of loss of the righting response (LORR) following administration of a sedative dose of ethanol. Four quantitative trait loci (QTLs) have been mapped in these strains for this trait. Genome-wide expression profiling in cerebellum was used here to identify candidate genes for regulatory region differences in these two strains. Fifteen differentially expressed genes were found that map to the QTL regions.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031170.2	NP_112447.2	NC_000081.5 range: 101827141..101834772, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005882	intermediate filament	Cellular Component	IDA (10747083)
GO:0042383	sarcolemma	Cellular Component	IDA (15247274)
GO:0030018	Z disc	Cellular Component	IDA (15247274)
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12857878)
GO:0000904	cellular morphogenesis during differentiation	Biological Process	TAS (2467842)
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	IMP (10747083)
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	IGI (10747083)
GO:0007275	multicellular organismal development	Biological Process	TAS (2467842)
GO:0006915	apoptosis	Biological Process	IMP (10747083)
GO:0051707	response to other organism	Biological Process	IMP (14576356)