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Gene Information
Gene ID:30805
Symbol:Slc22a4
Full Name:solute carrier family 22 (organic cation transporter), member 4
Alias:Octn1
Organism:Mus musculus (Mouse)
Chromosome:11
Genetic Location:11 B1.3|11 28.0 cM
Physical Location:53796627-53841591 on NC_000077.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6583    Symbol (Name): SLC22A4 (solute carrier family 22 (organic cation/ergothioneine transporter), member 4)
Ortholog Status:The human GeneID 6583 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Slc22a4
Fold Change:2.4
Note:More highly expressed in ILS
Dataset Information
Name:16465594
Method:Microarray and QTL
Tissue:Cerebellum
Phenotype:Ethanol sensitivity
Publication:MacLaren et al. Mamm Genome. (2006) Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. PubMed
Summary:The Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) mouse strains have a 16-fold difference in duration of loss of the righting response (LORR) following administration of a sedative dose of ethanol. Four quantitative trait loci (QTLs) have been mapped in these strains for this trait. Genome-wide expression profiling in cerebellum was used here to identify candidate genes for regulatory region differences in these two strains. Fifteen differentially expressed genes were found that map to the QTL regions.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Alcw3Acute Alcohol Withdrawal112016-28 (cM)4.11.00E-05SignificantPARC
Caws4/Alcw3Chronic Alcohol Withdrawal11 15-36 (cM)6.72.00E-07SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019687.3NP_062661.1NC_000077.5 range: 53796627..53841591, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0016020membraneCellular ComponentRCA (12466851)
GO:0005739mitochondrionCellular ComponentIDA (14651853|16729965)
GO:0005739mitochondrionCellular ComponentISO
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0015293symporter activityMolecular FunctionIEA
GO:0015226carnitine transporter activityMolecular FunctionISO
GO:0015226carnitine transporter activityMolecular FunctionIDA (11010964)
GO:0015075ion transmembrane transporter activityMolecular FunctionRCA (12466851)
GO:0031402sodium ion bindingMolecular FunctionIEA
GO:0005215transporter activityMolecular FunctionRCA (12466851)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0015879carnitine transportBiological ProcessISO
GO:0015879carnitine transportBiological ProcessIDA (11010964)
GO:0015697quaternary ammonium group transportBiological ProcessIDA (11010964)
GO:0006641triacylglycerol metabolic processBiological ProcessIGI (10655497)
GO:0006810transportBiological ProcessRCA (12466851)
GO:0006811ion transportBiological ProcessRCA (12466851)
GO:0006814sodium ion transportBiological ProcessIEA
GO:0009437carnitine metabolic processBiological ProcessIGI (10655497)
Other Database Cross Links
NCBI Entrez Gene:30805
MGI:
Ensembl:ENSMUSG00000020334
dbSNP:Slc22a4
AceView:Slc22a4