ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pcsk2

Full Name:

proprotein convertase subtilisin/kexin type 2

Alias:

6330411F23Rik|AI839700|Nec-2|Nec2|PC2|Phpp-2|SPC2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 F3-H2|2 81.4 cM

Physical Location:

143371914-143642019 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5126 Symbol (Name): PCSK2 (proprotein convertase subtilisin/kexin type 2)

Ortholog Status:

The human GeneID 5126 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		16465594
Method:		Microarray and QTL
Tissue:		Cerebellum
Phenotype:		Ethanol sensitivity
Publication:		MacLaren et al. Mamm Genome. (2006) Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. PubMed
Summary:		The Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) mouse strains have a 16-fold difference in duration of loss of the righting response (LORR) following administration of a sedative dose of ethanol. Four quantitative trait loci (QTLs) have been mapped in these strains for this trait. Genome-wide expression profiling in cerebellum was used here to identify candidate genes for regulatory region differences in these two strains. Fifteen differentially expressed genes were found that map to the QTL regions.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore2	Alcohol-induced Loss of Righting Reflex	2		75.6-81.7 (cM)	6.6		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008792.3	NP_032818.1	NC_000068.6 range: 143371914..143642019

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IDA (8397508)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0004252	serine-type endopeptidase activity	Molecular Function	IEA
GO:0004289	subtilase activity	Molecular Function	IEA
GO:0004286	proprotein convertase 2 activity	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	IMP (12859669)
GO:0016486	peptide hormone processing	Biological Process	IMP (12859669)
GO:0016540	protein autoprocessing	Biological Process	IDA (16893422)
GO:0007399	nervous system development	Biological Process	IEP (16893422)