ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

22596

Symbol:

Xrcc5

Full Name:

X-ray repair complementing defective repair in Chinese hamster cells 5

Alias:

AI314015|Ku80|Ku86

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 E|1 42.0 cM

Physical Location:

72354093-72441521 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7520 Symbol (Name): XRCC5 (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa))

Ortholog Status:

The human GeneID 7520 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Xrcc5
Fold Change:		2.5
Note:		More highly expressed in ISS

Dataset Information

Name:		16465594
Method:		Microarray and QTL
Tissue:		Cerebellum
Phenotype:		Ethanol sensitivity
Publication:		MacLaren et al. Mamm Genome. (2006) Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. PubMed
Summary:		The Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) mouse strains have a 16-fold difference in duration of loss of the righting response (LORR) following administration of a sedative dose of ethanol. Four quantitative trait loci (QTLs) have been mapped in these strains for this trait. Genome-wide expression profiling in cerebellum was used here to identify candidate genes for regulatory region differences in these two strains. Fifteen differentially expressed genes were found that map to the QTL regions.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws1/Alcw5	Chronic Alcohol Withdrawal	1		28-47 (cM)	6.5	3.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009533.2	NP_033559.2	NC_000067.5 range: 72354093..72441521

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (12604618)
GO:0005737	cytoplasm	Cellular Component	IDA (12604618)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004386	helicase activity	Molecular Function	IEA
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0050769	positive regulation of neurogenesis	Biological Process	IMP (10716994)
GO:0043066	negative regulation of apoptosis	Biological Process	IMP (17554309)
GO:0008283	cell proliferation	Biological Process	IMP (17554309)
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	IEA
GO:0006302	double-strand break repair	Biological Process	IMP (12531011)
GO:0006302	double-strand break repair	Biological Process	IGI (12531011)
GO:0060218	hemopoietic stem cell differentiation	Biological Process	IMP (17554309)