ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

XRCC5

Full Name:

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa)

Alias:

FLJ39089|KARP-1|KARP1|KU80|KUB2|Ku86|NFIV

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q35

Physical Location:

216682377-216779247 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 22596 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

XRCC5

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021141.2	NP_066964.1	NC_000002.10 range: 216682377..216779247

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005654	nucleoplasm	Cellular Component	EXP (12023295\|12065431)
GO:0005634	nucleus	Cellular Component	TAS (7957065)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005575	cellular_component	Cellular Component	ND
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12145306\|15075319)
GO:0005488	binding	Molecular Function	IEA
GO:0004386	helicase activity	Molecular Function	IEA
GO:0003674	molecular_function	Molecular Function	ND
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	NAS (1537839)
GO:0003690	double-stranded DNA binding	Molecular Function	TAS (7957065)
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function	IEA
GO:0004003	ATP-dependent DNA helicase activity	Molecular Function	TAS (7957065)
GO:0006282	regulation of DNA repair	Biological Process	NAS (9214634)
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	IEA
GO:0019047	provirus integration	Biological Process	EXP (16291214)
GO:0019059	initiation of viral infection	Biological Process	EXP (12091904)