ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Atf4

Full Name:

activating transcription factor 4

Alias:

Atf-4|C/ATF|CREB2|MGC96460|TAXREB67

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 E1|15 43.3 cM

Physical Location:

80085613-80087970 on NC_000081.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 468 Symbol (Name): ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67))

Ortholog Status:

The human GeneID 468 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC
Aaq1/Etacc	Alcohol Acceptance	15	30	15-48 (cM)	3.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009716.2	NP_033846.2	NC_000081.5 range: 80085613..80087970

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (15013631)
GO:0005667	transcription factor complex	Cellular Component	IC (11916968)
GO:0005667	transcription factor complex	Cellular Component	IDA (16751105)
GO:0005737	cytoplasm	Cellular Component	IDA (15013631)
GO:0003677	DNA binding	Molecular Function	IDA (12749859\|15724149)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0016563	transcription activator activity	Molecular Function	IDA (11916968)
GO:0046983	protein dimerization activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12749859\|15013631\|16751105)
GO:0003704	specific RNA polymerase II transcription factor activity	Molecular Function	IDA (12749859)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IGI (16751105)
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IDA (11916968)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (12749859)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IGI (15724149\|16751105)
GO:0006094	gluconeogenesis	Biological Process	IDA (11916968)