ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

B2m

Full Name:

beta-2 microglobulin

Alias:

Ly-m11|beta2-m

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 F1-F3|2 69.0 cM

Physical Location:

121973422-121978817 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 567 Symbol (Name): B2M (beta-2-microglobulin)

Ortholog Status:

The human GeneID 567 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		B2m
P Value:		0.005
Note:		Differentially expressed genes in brains of HAFT and LAFT mice. The P_value is the QTL P_value.

Dataset Information

Name:		12805289
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Acute functional tolerance to ethanol
Publication:		Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
Summary:		We describe a novel approach that uses a combination of selective breeding, quantitative trait locus analysis, and DNA microarray technology to identify candidate genes for the complex phenotype of ethanol tolerance. Tolerance that develops during a single exposure to alcohol is defined as acute functional tolerance (AFT). Lines of mice to display high acute functional tolerance (HAFT mice) and low acute functional tolerance (LAFT mice) to the incoordinating effect of ethanol were used.

Gene Information

Original ID1:

B2m

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009735.3	NP_033865.2	NC_000068.6 range: 121973422..121978817

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0042612	MHC class I protein complex	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (14735325)
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0006968	cellular defense response	Biological Process	TAS (2685607)