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Dataset Description
  • Dataset Name: 12805289
  • Species: Mouse
  • Method: Microarray and QTL
  • No. of Genes: 11
  • Tissue: Whole brain
  • Phenotype: Acute functional tolerance to ethanol
  • Publication: Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
  • Dataset Summary: We describe a novel approach that uses a combination of selective breeding, quantitative trait locus analysis, and DNA microarray technology to identify candidate genes for the complex phenotype of ethanol tolerance. Tolerance that develops during a single exposure to alcohol is defined as acute functional tolerance (AFT). Lines of mice to display high acute functional tolerance (HAFT mice) and low acute functional tolerance (LAFT mice) to the incoordinating effect of ethanol were used.

    Gene list of this dataset (11 genes)
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    14804Grid2glutamate receptor, ionotropic, delta 26 C1|6 29.65 cMGrid2 
    13643Efnb3ephrin B311 B3|11 40.0 cMEfnb3 
    14810Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)2 A3|2 12.0 cMGrin1 
    54683Prdx5peroxiredoxin 519 A|19 0.5 cMPrdx5 
    22671Zfp179zinc finger protein 17911 B1.3|11 34.35 cMZfp179 
    14799Gria1glutamate receptor, ionotropic, AMPA1 (alpha 1)11 B1.3|11 31.0 cMGria1 
    20336Exoc4exocyst complex component 46 A3.3|6 12.0 cMSec8 
    19360Rad50RAD50 homolog (S. cerevisiae)11 A5-B1|11 28.9 cMRad50 
    12386Ctnna2catenin (cadherin associated protein), alpha 26 B3-D|6 34.2 cMCatna2 
    12010B2mbeta-2 microglobulin2 F1-F3|2 69.0 cMB2m