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Gene Information
Gene ID:54683
Full Name:peroxiredoxin 5
Organism:Mus musculus (Mouse)
Genetic Location:19 A|19 0.5 cM
Physical Location:6981308-6984134 on NC_000085.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 25824    Symbol (Name): PRDX5 (peroxiredoxin 5)
Ortholog Status:The human GeneID 25824 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Prdx5
P Value:0.001
Note:Differentially expressed genes in brains of HAFT and LAFT mice. The P_value is the QTL P_value.
Dataset Information
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Acute functional tolerance to ethanol
Publication:Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
Summary:We describe a novel approach that uses a combination of selective breeding, quantitative trait locus analysis, and DNA microarray technology to identify candidate genes for the complex phenotype of ethanol tolerance. Tolerance that develops during a single exposure to alcohol is defined as acute functional tolerance (AFT). Lines of mice to display high acute functional tolerance (HAFT mice) and low acute functional tolerance (LAFT mice) to the incoordinating effect of ethanol were used.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012021.2NP_036151.1NC_000085.5 range: 6981308..6984134, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIDA (14651853)
GO:0005777peroxisomeCellular ComponentIEA
GO:0004601peroxidase activityMolecular FunctionIEA
GO:0016209antioxidant activityMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0051920peroxiredoxin activityMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:54683