ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rad50

Full Name:

RAD50 homolog (S. cerevisiae)

Alias:

Mrell|Rad50l

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 A5-B1|11 28.9 cM

Physical Location:

53463071-53520798 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10111 Symbol (Name): RAD50 (RAD50 homolog (S. cerevisiae))

Ortholog Status:

The human GeneID 10111 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rad50
P Value:		0.002
Note:		Differentially expressed genes in brains of HAFT and LAFT mice. The P_value is the QTL P_value.

Dataset Information

Name:		12805289
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Acute functional tolerance to ethanol
Publication:		Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
Summary:		We describe a novel approach that uses a combination of selective breeding, quantitative trait locus analysis, and DNA microarray technology to identify candidate genes for the complex phenotype of ethanol tolerance. Tolerance that develops during a single exposure to alcohol is defined as acute functional tolerance (AFT). Lines of mice to display high acute functional tolerance (HAFT mice) and low acute functional tolerance (LAFT mice) to the incoordinating effect of ethanol were used.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws4/Alcw3	Chronic Alcohol Withdrawal	11		15-36 (cM)	6.7	2.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009012.2	NP_033038.2	NC_000077.5 range: 53463071..53520798, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000781	chromosome, telomeric region	Cellular Component	IEA
GO:0045120	pronucleus	Cellular Component	IDA (17982445)
GO:0030870	Mre11 complex	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (17982445)
GO:0005694	chromosome	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004518	nuclease activity	Molecular Function	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0007126	meiosis	Biological Process	IEA
GO:0006281	DNA repair	Biological Process	IEA
GO:0006974	response to DNA damage stimulus	Biological Process	IEA