ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Exoc4

Full Name:

exocyst complex component 4

Alias:

C78892|Sec8|Sec8l1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 A3.3|6 12.0 cM

Physical Location:

33199149-33922942 on NC_000072.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 60412 Symbol (Name): EXOC4 (exocyst complex component 4)

Ortholog Status:

The human GeneID 60412 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Sec8
P Value:		0.001
Note:		Differentially expressed genes in brains of HAFT and LAFT mice. The P_value is the QTL P_value.

Dataset Information

Name:		12805289
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Acute functional tolerance to ethanol
Publication:		Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
Summary:		We describe a novel approach that uses a combination of selective breeding, quantitative trait locus analysis, and DNA microarray technology to identify candidate genes for the complex phenotype of ethanol tolerance. Tolerance that develops during a single exposure to alcohol is defined as acute functional tolerance (AFT). Lines of mice to display high acute functional tolerance (HAFT mice) and low acute functional tolerance (LAFT mice) to the incoordinating effect of ethanol were used.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009148.3	NP_033174.2	NC_000072.5 range: 33199149..33922942

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000145	exocyst	Cellular Component	IEA
GO:0030165	PDZ domain binding	Molecular Function	IPI (12738960)
GO:0006810	transport	Biological Process	IEA
GO:0006887	exocytosis	Biological Process	IEA
GO:0006904	vesicle docking during exocytosis	Biological Process	IEA
GO:0015031	protein transport	Biological Process	IEA