ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gria1

Full Name:

glutamate receptor, ionotropic, AMPA1 (alpha 1)

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B1.3|11 31.0 cM

Physical Location:

56825457-57143745 on NC_000077.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2890 Symbol (Name): GRIA1 (glutamate receptor, ionotropic, AMPA 1)

Ortholog Status:

The human GeneID 2890 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gria1
P Value:		0.002
Note:		Differentially expressed genes in brains of HAFT and LAFT mice. The P_value is the QTL P_value.

Dataset Information

Name:		12805289
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Acute functional tolerance to ethanol
Publication:		Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
Summary:		We describe a novel approach that uses a combination of selective breeding, quantitative trait locus analysis, and DNA microarray technology to identify candidate genes for the complex phenotype of ethanol tolerance. Tolerance that develops during a single exposure to alcohol is defined as acute functional tolerance (AFT). Lines of mice to display high acute functional tolerance (HAFT mice) and low acute functional tolerance (LAFT mice) to the incoordinating effect of ethanol were used.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws4/Alcw3	Chronic Alcohol Withdrawal	11		15-36 (cM)	6.7	2.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008165.3	NP_032191.2	NC_000077.5 range: 56825457..57143745

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	ISS (15681343)
GO:0030054	cell junction	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005624	membrane fraction	Cellular Component	IDA (17093100)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0014069	postsynaptic density	Cellular Component	IDA (12628184)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (14687553)
GO:0005234	extracellular-glutamate-gated ion channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0004970	ionotropic glutamate receptor activity	Molecular Function	IEA
GO:0007616	long-term memory	Biological Process	IMP (12628184)
GO:0006810	transport	Biological Process	IEA
GO:0031623	receptor internalization	Biological Process	IMP (12628184)
GO:0006811	ion transport	Biological Process	IEA