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Gene Information
Gene ID:13643
Symbol:Efnb3
Full Name:ephrin B3
Alias:EFL-6|ELF-3|Elk-L3|Epl8|LERK-8|NLERK-2
Organism:Mus musculus (Mouse)
Chromosome:11
Genetic Location:11 B3|11 40.0 cM
Physical Location:69367626-69373679 on NC_000077.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 1949    Symbol (Name): EFNB3 (ephrin-B3)
Ortholog Status:The human GeneID 1949 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Efnb3
P Value:0.002
Note:Differentially expressed genes in brains of HAFT and LAFT mice. The P_value is the QTL P_value.
Dataset Information
Name:12805289
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Acute functional tolerance to ethanol
Publication:Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
Summary:We describe a novel approach that uses a combination of selective breeding, quantitative trait locus analysis, and DNA microarray technology to identify candidate genes for the complex phenotype of ethanol tolerance. Tolerance that develops during a single exposure to alcohol is defined as acute functional tolerance (AFT). Lines of mice to display high acute functional tolerance (HAFT mice) and low acute functional tolerance (LAFT mice) to the incoordinating effect of ethanol were used.
Gene Information
Original ID1:Efnb3
Original ID2:AW121468
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Lore4Alcohol-induced Loss of Righting Reflex11 36-42 (cM)6.5 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007911.4NP_031937.1NC_000077.5 range: 69367626..69373679, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0016020membraneCellular ComponentIEA
GO:0046875ephrin receptor bindingMolecular FunctionISO
GO:0007411axon guidanceBiological ProcessIMP (11731465|12649481)
GO:0007628adult walking behaviorBiological ProcessIMP (11182083|12649481)
GO:0007399nervous system developmentBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0016198axon choice point recognitionBiological ProcessIMP (11182083)
GO:0030154cell differentiationBiological ProcessIEA
GO:0048013ephrin receptor signaling pathwayBiological ProcessISO
Other Database Cross Links
NCBI Entrez Gene:13643
MGI:
Ensembl:ENSMUSG00000003934
dbSNP:Efnb3
AceView:Efnb3