Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:14810
Symbol:Grin1
Full Name:glutamate receptor, ionotropic, NMDA1 (zeta 1)
Alias:GluRdelta1|NMDAR1|NR1|Nmdar
Organism:Mus musculus (Mouse)
Chromosome:2
Genetic Location:2 A3|2 12.0 cM
Physical Location:25147766-25174498 on NC_000068.6, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2902    Symbol (Name): GRIN1 (glutamate receptor, ionotropic, N-methyl D-aspartate 1)
Ortholog Status:The human GeneID 2902 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Grin1
P Value:0.006
Note:Differentially expressed genes in brains of HAFT and LAFT mice. The P_value is the QTL P_value.
Dataset Information
Name:12805289
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Acute functional tolerance to ethanol
Publication:Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
Summary:We describe a novel approach that uses a combination of selective breeding, quantitative trait locus analysis, and DNA microarray technology to identify candidate genes for the complex phenotype of ethanol tolerance. Tolerance that develops during a single exposure to alcohol is defined as acute functional tolerance (AFT). Lines of mice to display high acute functional tolerance (HAFT mice) and low acute functional tolerance (LAFT mice) to the incoordinating effect of ethanol were used.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008169.1NP_032195.1NC_000068.6 range: 25147766..25174498, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045211postsynaptic membraneCellular ComponentIDA (11754836|12890763|15317856)
GO:0005737cytoplasmCellular ComponentIDA (12414093)
GO:0008021synaptic vesicleCellular ComponentIDA (10846156)
GO:0014069postsynaptic densityCellular ComponentIDA (15317856|15748150)
GO:0016020membraneCellular ComponentIC (1532151)
GO:0016021integral to membraneCellular ComponentIEA
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexCellular ComponentIPI (9003035)
GO:0019717synaptosomeCellular ComponentIDA (14645471)
GO:0030054cell junctionCellular ComponentIEA
GO:0045202synapseCellular ComponentISO
GO:0045202synapseCellular ComponentIDA (16025111|16710293)
GO:0043197dendritic spineCellular ComponentIDA (15663482)
GO:0045202synapseCellular ComponentISS (15681343)
GO:0030426growth coneCellular ComponentNAS (10480904)
GO:0005624membrane fractionCellular ComponentIDA (8840015|9003035|10846156|17093100)
GO:0035254glutamate receptor bindingMolecular FunctionISS (7929101)
GO:0035254glutamate receptor bindingMolecular FunctionIPI (9003035|14645471)
GO:0016594glycine bindingMolecular FunctionIMP (12586454)
GO:0005516calmodulin bindingMolecular FunctionIDA (15663482)
GO:0005234extracellular-glutamate-gated ion channel activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0005102receptor bindingMolecular FunctionIDA (11754835)
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityMolecular FunctionISS (7929101)
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityMolecular FunctionIMP (8313466)
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityMolecular FunctionIGI (1374164|1377365|7531804)
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityMolecular FunctionIDA (1374164|1377365|1385220|1532151)
GO:0004970ionotropic glutamate receptor activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0005261cation channel activityMolecular FunctionIGI (7531804)
GO:0005262calcium channel activityMolecular FunctionIDA (1374164|1532151)
GO:0005262calcium channel activityMolecular FunctionIGI (1374164)
GO:0005509calcium ion bindingMolecular FunctionIDA (15663482)
GO:0005515protein bindingMolecular FunctionIPI (8595214|9458051|11754835|15663482|16554481)
GO:0006811ion transportBiological ProcessIEA
GO:0001967suckling behaviorBiological ProcessIMP (8313466|8713451)
GO:0008542visual learningBiological ProcessIMP (8980238|9246451)
GO:0006810transportBiological ProcessIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (7907365)
GO:0048167regulation of synaptic plasticityBiological ProcessIMP (8980238|8980239|9246451)
GO:0050905neuromuscular processBiological ProcessIMP (8313466)
GO:0055074calcium ion homeostasisBiological ProcessIDA (7907365)
GO:0060079regulation of excitatory postsynaptic membrane potentialBiological ProcessIGI (14645471)
GO:0043523regulation of neuron apoptosisBiological ProcessIGI (10479699)
GO:0006812cation transportBiological ProcessIGI (7531804)
GO:0042391regulation of membrane potentialBiological ProcessIDA (1532151)
GO:0008542visual learningBiological ProcessIGI (9054942)
GO:0008344adult locomotory behaviorBiological ProcessIMP (10481908)
GO:0021586pons maturationBiological ProcessIMP (8313466)
GO:0007585respiratory gaseous exchangeBiological ProcessIMP (8313466|8713451)
GO:0035176social behaviorBiological ProcessIMP (10481908)
GO:0035235ionotropic glutamate receptor signaling pathwayBiological ProcessIDA (16025111)
GO:0035249synaptic transmission, glutamatergicBiological ProcessIMP (8313466)
GO:0007268synaptic transmissionBiological ProcessTAS (10846156)
GO:0006816calcium ion transportBiological ProcessIDA (1532151)
GO:0060179male mating behaviorBiological ProcessIMP (10481908)
Other Database Cross Links
NCBI Entrez Gene:14810
MGI:
Ensembl:ENSMUSG00000026959
dbSNP:Grin1
AceView:Grin1