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Gene Information
Gene ID:2902
Full Name:glutamate receptor, ionotropic, N-methyl D-aspartate 1
Organism:Homo sapiens (Human)
Genetic Location:9q34.3
Physical Location:139153429-139183028 on NC_000009.10
Gene Type:protein-coding
Orthologs:This gene has Mouse: 14810 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:GRIN1
Dataset Information
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Information
Original ID1:GRIN1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
GRIN11Alcohol-Induced Disorders
GRIN11Alcohol-Induced Disorders Nervous System
GRIN12Alcohol-Related Disorders
GRIN11Alcohol Withdrawal Seizures
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000832.5NP_000823.4NC_000009.10 range: 139153429..139183028
NM_007327.2NP_015566.1NC_000009.10 range: 139153429..139183028
NM_021569.2NP_067544.1NC_000009.10 range: 139153429..139183028
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0008021synaptic vesicleCellular ComponentISS
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexCellular ComponentIDA (7679115|10480938|17047094)
GO:0005887integral to plasma membraneCellular ComponentIDA (7685113)
GO:0005886plasma membraneCellular ComponentIEA
GO:0019717synaptosomeCellular ComponentISS
GO:0030054cell junctionCellular ComponentIEA
GO:0030425dendriteCellular ComponentIDA (10749211)
GO:0045211postsynaptic membraneCellular ComponentISS
GO:0014069postsynaptic densityCellular ComponentISS
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentISS
GO:0045202synapseCellular ComponentIEA
GO:0016594glycine bindingMolecular FunctionIMP (17047094)
GO:0035254glutamate receptor bindingMolecular FunctionISS
GO:0016594glycine bindingMolecular FunctionIDA (7685113)
GO:0016595glutamate bindingMolecular FunctionIDA (7685113)
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0005234extracellular-glutamate-gated ion channel activityMolecular FunctionIEA
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityMolecular FunctionIDA (7679115|7685113)
GO:0004970ionotropic glutamate receptor activityMolecular FunctionIEA
GO:0005262calcium channel activityMolecular FunctionIDA (7685113)
GO:0005509calcium ion bindingMolecular FunctionISS
GO:0005516calmodulin bindingMolecular FunctionISS
GO:0004872receptor activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0055074calcium ion homeostasisBiological ProcessISS
GO:0042391regulation of membrane potentialBiological ProcessIDA (7679115|7685113|17047094)
GO:0008542visual learningBiological ProcessISS
GO:0035235ionotropic glutamate receptor signaling pathwayBiological ProcessISS
GO:0006811ion transportBiological ProcessIEA
GO:0006812cation transportBiological ProcessIDA (7685113)
GO:0007268synaptic transmissionBiological ProcessISS
GO:0060079regulation of excitatory postsynaptic membrane potentialBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:2902
HuGE Navigator:2902