ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Grid2

Full Name:

glutamate receptor, ionotropic, delta 2

Alias:

B230104L07Rik|GluRdelta2|Lc|Lc|MMS10-AC|Ms10ac|cpr|ho|nmf408|tpr

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 C1|6 29.65 cM

Physical Location:

63206850-64616272 on NC_000072.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2895 Symbol (Name): GRID2 (glutamate receptor, ionotropic, delta 2)

Ortholog Status:

The human GeneID 2895 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Grid2
P Value:		0.006
Note:		Differentially expressed genes in brains of HAFT and LAFT mice. The P_value is the QTL P_value.

Dataset Information

Name:		12805289
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Acute functional tolerance to ethanol
Publication:		Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
Summary:		We describe a novel approach that uses a combination of selective breeding, quantitative trait locus analysis, and DNA microarray technology to identify candidate genes for the complex phenotype of ethanol tolerance. Tolerance that develops during a single exposure to alcohol is defined as acute functional tolerance (AFT). Lines of mice to display high acute functional tolerance (HAFT mice) and low acute functional tolerance (LAFT mice) to the incoordinating effect of ethanol were used.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_008167.2	NP_032193.1	NC_000072.5 range: 63206850..64616272

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0019717	synaptosome	Cellular Component	IDA (12372286)
GO:0005624	membrane fraction	Cellular Component	IDA (15579147)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11826110\|12372286\|15579147)
GO:0005234	extracellular-glutamate-gated ion channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0004970	ionotropic glutamate receptor activity	Molecular Function	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0035249	synaptic transmission, glutamatergic	Biological Process	IMP (7766857)
GO:0060079	regulation of excitatory postsynaptic membrane potential	Biological Process	IMP (7766857)
GO:0060134	prepulse inhibition	Biological Process	IMP (11488959)