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Gene Information
Gene ID:14804
Full Name:glutamate receptor, ionotropic, delta 2
Organism:Mus musculus (Mouse)
Genetic Location:6 C1|6 29.65 cM
Physical Location:63206850-64616272 on NC_000072.5
Gene Type:protein-coding
Human Ortholog:GeneID: 2895    Symbol (Name): GRID2 (glutamate receptor, ionotropic, delta 2)
Ortholog Status:The human GeneID 2895 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Grid2
P Value:0.006
Note:Differentially expressed genes in brains of HAFT and LAFT mice. The P_value is the QTL P_value.
Dataset Information
Method:Microarray and QTL
Tissue:Whole brain
Phenotype:Acute functional tolerance to ethanol
Publication:Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
Summary:We describe a novel approach that uses a combination of selective breeding, quantitative trait locus analysis, and DNA microarray technology to identify candidate genes for the complex phenotype of ethanol tolerance. Tolerance that develops during a single exposure to alcohol is defined as acute functional tolerance (AFT). Lines of mice to display high acute functional tolerance (HAFT mice) and low acute functional tolerance (LAFT mice) to the incoordinating effect of ethanol were used.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_008167.2NP_032193.1NC_000072.5 range: 63206850..64616272
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0019717synaptosomeCellular ComponentIDA (12372286)
GO:0005624membrane fractionCellular ComponentIDA (15579147)
GO:0016021integral to membraneCellular ComponentIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (11826110|12372286|15579147)
GO:0005234extracellular-glutamate-gated ion channel activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0004970ionotropic glutamate receptor activityMolecular FunctionIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006810transportBiological ProcessIEA
GO:0035249synaptic transmission, glutamatergicBiological ProcessIMP (7766857)
GO:0060079regulation of excitatory postsynaptic membrane potentialBiological ProcessIMP (7766857)
GO:0060134prepulse inhibitionBiological ProcessIMP (11488959)
Other Database Cross Links
NCBI Entrez Gene:14804