ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ctnna2

Full Name:

catenin (cadherin associated protein), alpha 2

Alias:

AI481747|Catna|Catna2|cdf|chp

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 B3-D|6 34.2 cM

Physical Location:

76831645-77929581 on NC_000072.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1496 Symbol (Name): CTNNA2 (catenin (cadherin-associated protein), alpha 2)

Ortholog Status:

The human GeneID 1496 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Catna2
P Value:		0.006
Note:		Differentially expressed genes in brains of HAFT and LAFT mice. The P_value is the QTL P_value.

Dataset Information

Name:		12805289
Method:		Microarray and QTL
Tissue:		Whole brain
Phenotype:		Acute functional tolerance to ethanol
Publication:		Tabakoff et al. J Neurosci. (2003) Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. PubMed
Summary:		We describe a novel approach that uses a combination of selective breeding, quantitative trait locus analysis, and DNA microarray technology to identify candidate genes for the complex phenotype of ethanol tolerance. Tolerance that develops during a single exposure to alcohol is defined as acute functional tolerance (AFT). Lines of mice to display high acute functional tolerance (HAFT mice) and low acute functional tolerance (LAFT mice) to the incoordinating effect of ethanol were used.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030027	lamellipodium	Cellular Component	IDA (14657280)
GO:0016323	basolateral plasma membrane	Cellular Component	IDA (9950951)
GO:0015629	actin cytoskeleton	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0005913	cell-cell adherens junction	Cellular Component	IDA (15630473)
GO:0005912	adherens junction	Cellular Component	IDA (12695331)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0007155	cell adhesion	Biological Process	IEA
GO:0048854	brain morphogenesis	Biological Process	IMP (16691566)