ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Bckdha

Full Name:

branched chain ketoacid dehydrogenase E1, alpha polypeptide

Organism:

Mus musculus (Mouse)

Chromosome:

Physical Location:

26414964-26443755 on NC_000073.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 593 Symbol (Name): BCKDHA (branched chain keto acid dehydrogenase E1, alpha polypeptide)

Ortholog Status:

The human GeneID 593 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		L47335
Note:		Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains

Dataset Information

Name:		15282116
Method:		Microarray
Tissue:		Striata
Phenotype:		Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration
Publication:		Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed
Summary:		Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007533.5	NP_031559.3	NC_000073.5 range: 26414964..26443755, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	Molecular Function	IEA
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	Molecular Function	IEA
GO:0016536	cyclin-dependent protein kinase 5 activator regulator activity	Molecular Function	IDA (11331592)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA (11331592)