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Gene Information
Gene ID:12043
Symbol:Bcl2
Full Name:B-cell leukemia/lymphoma 2
Alias:AW986256|Bcl-2|C430015F12Rik|D630044D05Rik|D830018M01Rik
Organism:Mus musculus (Mouse)
Chromosome:1
Genetic Location:1 E2.1|1 59.8 cM
Physical Location:108434755-108610866 on NC_000067.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 596    Symbol (Name): BCL2 (B-cell CLL/lymphoma 2)
Ortholog Status:The human GeneID 596 is also in human dataset(s).
Gene in Ethanol Study Datasets
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Ap1qAlcohol Preference Drinking17645-95 (cM)4.5 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009741.3NP_033871.2NC_000067.5 range: 108434755..108610866, complement
NM_177410.2NP_803129.2NC_000067.5 range: 108434755..108610866, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005955calcineurin complexCellular ComponentIDA (12617961)
GO:0016020membraneCellular ComponentISS (7896880)
GO:0005737cytoplasmCellular ComponentIDA (7563251|7675327|8030757)
GO:0005829cytosolCellular ComponentIDA (8030757|12050152|14551195)
GO:0005792microsomeCellular ComponentIDA (7945396|7953633)
GO:0005783endoplasmic reticulumCellular ComponentIDA (8030757)
GO:0005739mitochondrionCellular ComponentISS (7896880)
GO:0005739mitochondrionCellular ComponentIDA (7945396|7953633|12420306|14651853)
GO:0005622intracellularCellular ComponentIDA (9008714|9252127|11146504)
GO:0005624membrane fractionCellular ComponentIDA (8030757)
GO:0005634nucleusCellular ComponentIDA (7945396|7953633|8030757)
GO:0005634nucleusCellular ComponentISS (7546744|7896880)
GO:0016021integral to membraneCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentISS (7546744)
GO:0000159protein phosphatase type 2A complexCellular ComponentIDA (16717086)
GO:0043209myelin sheathCellular ComponentIDA (7953633)
GO:0031965nuclear membraneCellular ComponentIDA (8030757)
GO:0031966mitochondrial membraneCellular ComponentIDA (11980919)
GO:0008134transcription factor bindingMolecular FunctionIPI (17382917)
GO:0046982protein heterodimerization activityMolecular FunctionIPI (10582606|11226327)
GO:0016563transcription activator activityMolecular FunctionIDA (17382917)
GO:0005515protein bindingMolecular FunctionIPI (12617961|15136728|16717086|17274640)
GO:0042981regulation of apoptosisBiological ProcessIGI (15818405)
GO:0043375CD8-positive, alpha-beta T cell lineage commitmentBiological ProcessIMP (8170972)
GO:0043029T cell homeostasisBiological ProcessIGI (17591857)
GO:0043066negative regulation of apoptosisBiological ProcessIDA (14707049|15983387)
GO:0043085positive regulation of catalytic activityBiological ProcessIMP (17382917)
GO:0043066negative regulation of apoptosisBiological ProcessIMP (8170972)
GO:0043067regulation of programmed cell deathBiological ProcessIGI (16672320)
GO:0042542response to hydrogen peroxideBiological ProcessIMP (12855558)
GO:0043066negative regulation of apoptosisBiological ProcessISS (7650367)
GO:0043029T cell homeostasisBiological ProcessIMP (7650488|8170972)
GO:0035265organ growthBiological ProcessIMP (7812968|8623928)
GO:0030336negative regulation of cell migrationBiological ProcessIMP (15292044)
GO:0031069hair follicle morphogenesisBiological ProcessIMP (8402909)
GO:0031103axon regenerationBiological ProcessIDA (9009190)
GO:0032835glomerulus developmentBiological ProcessIMP (8623928)
GO:0032880regulation of protein localizationBiological ProcessIMP (9950951)
GO:0033033negative regulation of myeloid cell apoptosisBiological ProcessIDA (9202146)
GO:0031647regulation of protein stabilityBiological ProcessIMP (14660795)
GO:0033077T cell differentiation in the thymusBiological ProcessIMP (8170972|9028316)
GO:0033689negative regulation of osteoblast proliferationBiological ProcessIMP (10193316)
GO:0034097response to cytokine stimulusBiological ProcessIMP (12855558)
GO:0034097response to cytokine stimulusBiological ProcessISS (9184696)
GO:0040007growthBiological ProcessIMP (7812968|8170972)
GO:0040018positive regulation of multicellular organism growthBiological ProcessIMP (11709185)
GO:0042100B cell proliferationBiological ProcessISS (1373874)
GO:0042221response to chemical stimulusBiological ProcessIDA (7595537)
GO:0042493response to drugBiological ProcessIDA (9098922)
GO:0042493response to drugBiological ProcessISS (8949945)
GO:0030318melanocyte differentiationBiological ProcessIMP (8758925|11709185|12086670)
GO:0043473pigmentationBiological ProcessIMP (8402909)
GO:0043524negative regulation of neuron apoptosisBiological ProcessIDA (7472523|8625820)
GO:0048538thymus developmentBiological ProcessIMP (9241272|15818405)
GO:0048545response to steroid hormone stimulusBiological ProcessIMP (8170972)
GO:0048547gut morphogenesisBiological ProcessIMP (7812968)
GO:0048589developmental growthBiological ProcessIMP (15818405)
GO:0048599oocyte developmentBiological ProcessIMP (7628407)
GO:0048743positive regulation of skeletal muscle fiber developmentBiological ProcessIMP (11146504)
GO:0048753pigment granule organization and biogenesisBiological ProcessIMP (8758925)
GO:0048873homeostasis of number of cells within a tissueBiological ProcessIMP (9241272|16427619)
GO:0050790regulation of catalytic activityBiological ProcessIMP (9681465)
GO:0051384response to glucocorticoid stimulusBiological ProcessIDA (8313913)
GO:0051384response to glucocorticoid stimulusBiological ProcessIMP (8372353)
GO:0051402neuron apoptosisBiological ProcessIGI (10762311)
GO:0051402neuron apoptosisBiological ProcessIMP (7546744)
GO:0051726regulation of cell cycleBiological ProcessIMP (10200548)
GO:0051789response to protein stimulusBiological ProcessIMP (9374413)
GO:0051881regulation of mitochondrial membrane potentialBiological ProcessIDA (9843949)
GO:0048538thymus developmentBiological ProcessIGI (15818405)
GO:0048536spleen developmentBiological ProcessIMP (15818405)
GO:0043524negative regulation of neuron apoptosisBiological ProcessIMP (9681465|10762311|11027399)
GO:0043524negative regulation of neuron apoptosisBiological ProcessISS (7546744)
GO:0043583ear developmentBiological ProcessIGI (11709185)
GO:0043583ear developmentBiological ProcessIMP (8170972|11709185)
GO:0045069regulation of viral genome replicationBiological ProcessIDA (16950491)
GO:0045636positive regulation of melanocyte differentiationBiological ProcessIMP (16427619)
GO:0045930negative regulation of mitotic cell cycleBiological ProcessIDA (9241272)
GO:0046671negative regulation of retinal cell programmed cell deathBiological ProcessIMP (10321489)
GO:0046902regulation of mitochondrial membrane permeabilityBiological ProcessIDA (9843949)
GO:0048041focal adhesion formationBiological ProcessIMP (15292044)
GO:0048066pigmentation during developmentBiological ProcessIGI (11709185)
GO:0048066pigmentation during developmentBiological ProcessIMP (8170972|11709185)
GO:0048070regulation of pigmentation during developmentBiological ProcessIGI (15818405)
GO:0048087positive regulation of pigmentation during developmentBiological ProcessIGI (9241272)
GO:0048087positive regulation of pigmentation during developmentBiological ProcessIMP (10674380)
GO:0048536spleen developmentBiological ProcessIGI (15818405)
GO:0051924regulation of calcium ion transportBiological ProcessISS (8022822)
GO:0030318melanocyte differentiationBiological ProcessIGI (12086670)
GO:0000082G1/S transition of mitotic cell cycleBiological ProcessIMP (12855558|14660795)
GO:0002320lymphoid progenitor cell differentiationBiological ProcessIMP (9028316)
GO:0002326B cell lineage commitmentBiological ProcessIMP (8788039)
GO:0002360T cell lineage commitmentBiological ProcessIMP (8788039)
GO:0002520immune system developmentBiological ProcessIMP (7812968|8372353)
GO:0003014renal system processBiological ProcessIMP (8760259)
GO:0000082G1/S transition of mitotic cell cycleBiological ProcessIDA (14660795)
GO:0006470protein amino acid dephosphorylationBiological ProcessIDA (16717086)
GO:0006582melanin metabolic processBiological ProcessIMP (11709185)
GO:0006800oxygen and reactive oxygen species metabolic processBiological ProcessIMP (9681465|10726970|12855558)
GO:0006808regulation of nitrogen utilizationBiological ProcessIGI (9241272)
GO:0006874cellular calcium ion homeostasisBiological ProcessIDA (7945396)
GO:0006915apoptosisBiological ProcessIDA (8358790)
GO:0006916anti-apoptosisBiological ProcessIDA (7751019|7834747|8313913|9560217|14551195|14660795|17267035)
GO:0006916anti-apoptosisBiological ProcessIGI (7834747|12082633)
GO:0006916anti-apoptosisBiological ProcessIMP (7840250|8623928|8663032|8760259|9153592|9374413|9681465|10200548|10321489|10602483|12855558|14660795)
GO:0002260lymphocyte homeostasisBiological ProcessIMP (8170972|11709185)
GO:0002260lymphocyte homeostasisBiological ProcessIGI (11709185|15818405)
GO:0001952regulation of cell-matrix adhesionBiological ProcessIMP (15292044)
GO:0000209protein polyubiquitinationBiological ProcessISS (16717086)
GO:0000902cell morphogenesisBiological ProcessIMP (10193316)
GO:0001101response to acidBiological ProcessIDA (7675327)
GO:0001503ossificationBiological ProcessIMP (10193316)
GO:0001541ovarian follicle developmentBiological ProcessIMP (7628407)
GO:0001656metanephros developmentBiological ProcessIMP (7840250|8623928)
GO:0001657ureteric bud developmentBiological ProcessIMP (8623928)
GO:0001658ureteric bud branchingBiological ProcessIDA (14699151)
GO:0001658ureteric bud branchingBiological ProcessIGI (16672320)
GO:0001662behavioral fear responseBiological ProcessIMP (16095731)
GO:0001776leukocyte homeostasisBiological ProcessIMP (9028316)
GO:0001782B cell homeostasisBiological ProcessIMP (7650488|8170972)
GO:0001822kidney developmentBiological ProcessIGI (9241272|11709185|16672320)
GO:0001822kidney developmentBiological ProcessIMP (7812968|7840250|8760259|9950951|11709185|15818405|16282979)
GO:0001836release of cytochrome c from mitochondriaBiological ProcessIDA (9843949|14660795)
GO:0006916anti-apoptosisBiological ProcessISS (1373874|7772249|8050499|8080725)
GO:0006979response to oxidative stressBiological ProcessIMP (12855558)
GO:0010559regulation of glycoprotein biosynthetic processBiological ProcessIMP (15292044)
GO:0014031mesenchymal cell developmentBiological ProcessIMP (8623928)
GO:0014042positive regulation of neuron maturationBiological ProcessIMP (9547242)
GO:0014911positive regulation of smooth muscle cell migrationBiological ProcessIMP (17382917)
GO:0016049cell growthBiological ProcessIMP (8084613)
GO:0016337cell-cell adhesionBiological ProcessIMP (15292044)
GO:0018105peptidyl-serine phosphorylationBiological ProcessIDA (14660795)
GO:0018107peptidyl-threonine phosphorylationBiological ProcessIDA (14660795)
GO:0021747cochlear nucleus developmentBiological ProcessIMP (11027399)
GO:0022612gland morphogenesisBiological ProcessIMP (7812968)
GO:0030097hemopoiesisBiological ProcessIMP (7812968)
GO:0030183B cell differentiationBiological ProcessIMP (8170972|9028316)
GO:0030217T cell differentiationBiological ProcessIMP (8170972)
GO:0030279negative regulation of ossificationBiological ProcessIMP (9008714)
GO:0030307positive regulation of cell growthBiological ProcessISS (8022822)
GO:0010468regulation of gene expressionBiological ProcessIMP (12855558|15292044)
GO:0010332response to gamma radiationBiological ProcessIMP (8170972|8372353|10815637|17068116)
GO:0010224response to UV-BBiological ProcessIMP (10200548)
GO:0007015actin filament organizationBiological ProcessIMP (9950951)
GO:0007409axonogenesisBiological ProcessIMP (9009190)
GO:0007569cell agingBiological ProcessIMP (8372353)
GO:0008219cell deathBiological ProcessIMP (8170972|8372353)
GO:0008219cell deathBiological ProcessISS (8022822|8949945)
GO:0008283cell proliferationBiological ProcessIGI (10762311)
GO:0008284positive regulation of cell proliferationBiological ProcessIDA (11983915|17267035)
GO:0008285negative regulation of cell proliferationBiological ProcessIMP (8663032)
GO:0008584male gonad developmentBiological ProcessIGI (9241272)
GO:0009605response to external stimulusBiological ProcessIMP (10488913)
GO:0009636response to toxinBiological ProcessIMP (10602483)
GO:0009636response to toxinBiological ProcessISS (16717086)
GO:0009791post-embryonic developmentBiological ProcessIGI (9241272|11709185)
GO:0009791post-embryonic developmentBiological ProcessIMP (7812968|8170972|8755480|10674380|11709185)
GO:0009887organ morphogenesisBiological ProcessIMP (8170972)
GO:0030308negative regulation of cell growthBiological ProcessIMP (12855558)
Other Database Cross Links
NCBI Entrez Gene:12043
MGI:
Ensembl:ENSMUSG00000057329
dbSNP:Bcl2
AceView:Bcl2